A recent publication by Dr. Musa M. Musa and co-workers was selected as the back cover of ChemCatChem (8, 2016). In this work, a single-enzyme-mediated two-step approach for deracemization of secondary alcohols has been developed. A single mutant of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase enables the non-stereoselective oxidation of racemic alcohols to ketones, followed by a stereoselective reduction process. Varying the amounts of acetone and 2-propanol cosubstrates controls the stereoselectivities of the consecutive oxidation and reduction reactions, respectively. One enzyme was used to accomplish a deracemization of secondary alcohols with up to >99% ee and >99 % recovery in one pot and without the need to isolate the prochiral ketone intermediate. This is the first report of a single enzymatic one-pot deracemization reaction of secondary alcohols. More information can be found in Karume et al., ChemCatChem 2016, 8, 1459-1463.